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August 31, 2006

Genetically Modified Maize Vaccine can aid Farmers in Developing Nations

In many developing nations around the world, small-scale farmers often rely upon poultry farming solely for their livelihood. Unfortunately, for many of these farmers, this livelihood has been affected by the Newcastle Disease Virus (NDV), a contagious and fatal viral disease that infects a wide range of both domestic and wild birds, including chickens. NDV also has a devastating effect on commercial poultry production. Since vaccines for poultry are too costly for these farmers who eke out very meager livings, a cost effective solution needed to be developed. Fortunately, researchers in Mexico have done just that.

Researchers in Mexico have been able to genetically modify maize crops to create an edible vaccine for poultry against the Newcastle Disease Virus. The researchers, including Octavio Guerrero-Andrade of the Center for Research and Advanced Studies (CINVESTAV) in Guanajuato, inserted a gene from the Newcastle Disease Virus into the maize crops’ DNA. Chickens that ate the genetically modified (GM) maize produced antibodies against the virus. The maize also provided a level of protection against infection comparable to that of commercial vaccines.

The researchers’ findings were published online in Transgenic Research earlier this month. They hope these genetically modified maize crops can help small-scale poultry farmers protect their flocks from NDV.

“The disease is important and a big killer,” said Frands Dolberg of the Network for Smallholder Poultry Development, which works with partners in developing countries to promote poultry farming as a way of improving livelihoods.

According to the findings, vaccines against the disease that can be given to poultry through food already exist, but are not usually available in the small quantities that are often required by single families or villages.

“There is a big problem in delivering the vaccine to the many millions of poor poultry keepers around the world, and the genetically modified (GM) maize could be a possibility,” said Frands Dolberg.

Farmers in developing nations struggle every day to make a living against unfavorable conditions. They also struggle to access new technologies that can help better their lives, including getting vital vaccines that can save their poultry farms. With this genetically modified maize that the researchers in Mexico have developed, these needed vaccines will be easily accessible, less costly, and won’t require refrigeration like traditional vaccines do. It will ultimately help save and secure the farmers’ futures.

USDA issues biotechnology report: Opportunities and Challenges in Agricultural Biotechnology: The Decade Ahead

Here's an interesting article regarding a report on the future of biotechnology.

Alisa

USDA issues biotechnology report: Opportunities and Challenges in Agricultural Biotechnology: The Decade Ahead
USDA via SeedQuest
August 31, 2006

Deputy Agriculture Secretary Chuck Conner announced today that a report about the future of biotechnology is available to the public.

Prepared by USDA's Advisory Committee on Biotechnology and 21st Century Agriculture (AC21), "Opportunities and Challenges in Agricultural Biotechnology: The Decade Ahead" describes the advances in agricultural biotechnology's first decade and discusses a range of topics related to agricultural biotechnology that may be addressed by the secretary over the next decade.

"We are pleased to get this report and thank those involved for their interest and efforts. This consensus report, from a diverse group of stakeholders who express different perspectives, will be important in helping us understand the evolving landscape for agricultural biotechnology," said Conner.

The AC21 was established in 2003 to examine how biotechnology is likely to change agriculture and USDA's work over the long term. The 20-member committee represents a wide spectrum of views and interests and is composed of farmers, technology providers, academics, representatives from the food manufacturing and shipping industries, and representatives from consumer and environmental organizations. The committee meets in public session three to four times per year.

The web site for the AC21, which contains all the committee's reports and information about its meetings, can be accessed at: http://www.usda.gov/agency/oc/design/test/biotech/ac21.html.

Anti-GM gloaters

Here's a very interesting post by a fellow blogger defending China's GM crops from anti-GM bloggers and environmentalist groups like Greenpeace.

Enjoy !
Alisa

Anti-GM gloaters
Skeptico Blog via AgBioWorld
8/30/06

It never fails to amaze me how much the anti-Genetic Modification (GM) crowd love to gloat at any problems (real or perceived) with GM crops. Reader Paul sent me a link to this Science Blogs Effect Measure article claiming GM cotton resistant to bollworm planted in China, is proving to be “a curse”, since other pests have grown stronger:

Genetically modified cotton resistant to bollworm is a reality and five million Chinese cotton farmers have embraced it. It works, too, killing bollworm larvae that used to kill their cotton. IN the late 1990s it looked like a miracle. Pesticide use was cut by 70%. After seven years, though, the miracle is looking more like a curse because new pests called mirids have rushed into the pest vacuum and taken up shop.

To read more, go to http://skeptico.blogs.com/skeptico/2006/08/gm_cotton_china.html

August 30, 2006

Soybeans sprout new alliance

Here's an interesting article on a new collaboration regarding different uses for soybeans, including genetic modification and biofuels.

Best,
Alisa

Soybeans sprout new alliance
By Rachel Melcer
St. Louis Post-Dispatch
August 30, 2006

Bunge North America Inc., based in Maryland Heights, and DuPont's Agriculture and Nutrition group are teaming up to see just how much can be squeezed from a soybean.

The companies, which three years ago formed St. Louis-based Solae Co. to improve soy foods and created the Bunge DuPont Biotech Alliance, said Tuesday their focus is moving beyond human food.

The biotech alliance will find ways soybeans can yield oils for industrial use, greater quantities of biodiesel fuel and more nutritious animal feed, said Erik Fyrwald, group vice president of DuPont Agriculture and Nutrition. Resulting products will carry a new brand name, Treus -- pronounced TREE-us..

With about 20 people based at Bunge's headquarters, the alliance will draw upon each founder's expertise:

•DuPont's Pioneer Hi-Bred International Inc. subsidiary, based in Des Moines, Iowa, will sort seed to find and breed those with optimal end-use traits, as well as adding other useful qualities through genetic engineering.

•DuPont is working to develop improved and more economical biofuels, including soybean-based biodiesel.

•Bunge, which operates grain elevators, oilseed-processing plants, refineries for edible oils and packaging facilities, will help refine processing methods and identify customers.

Solae, a $1.1 billion company that brings improved soy protein food products to market, may be among the alliance's customers. In particular, it would be interested in soybeans genetically modified for higher content of healthy Omega 3 fatty acids, Fyrwald said.

In soybean-based food, fuel and fiber, "We just see a critically big opportunity for growth," Fyrwald said.

"At a time when there's so much market opportunity and so much technology, collaborating to bring things to market quickly and leverage others' expertise with your own is an essential ingredient to success," he added.

Bunge and DuPont are not alone in seeing green in soybeans.

Monsanto Co. of Creve Coeur, the world's leading developer of biotech crops, is pursuing many of the same targets. Other competitors are Syngenta AG, a Swiss agribusiness, and Bayer CropScience of Raleigh, N.C., a unit of German conglomerate Bayer AG.

Soybean growers, too, are promoting novel and increased uses of their crop. The United Soybean Board funds research and marketing efforts. Grower cooperatives are among producers and innovators in biofuels.

Bob Callanan, spokesman for the Creve Coeur-based American Soybean Association, said growers welcome any effort to improve soybeans and their market. But it is unclear how much the Bunge-DuPont alliance will accomplish.

The alliance's only product so far, soybeans with low-linolenic oil that ultimately reduce harmful trans fats in food, were planted on 35,000 acres in 2005 when they were introduced. This year 200,000 acres were planted and next year that will more than double, Fyrwald said.

The alliance product pipeline includes soybeans genetically modified to further reduce the need for trans fat-producing hydrogenation of packaged foods -- and, in early testing, is proving useful as an environmentally friendly industrial oil, Fyrwald said.

The alliance also is developing biotech soybeans with improved protein content, which boosts the nutritional and monetary value of an animal feed co-product of biodiesel production. Another effort seeks to increase overall yield per acre.

"We're still very focused on nutrition," said Troy Hobbs, alliance business manager. "But we're also focused on sustainability … and functionality."

India announces launch of Asia biotech meeting

Here's an article on the launch of an annual biotech meeting in Asia.

Alisa

India announces launch of Asia biotech meeting
The Hindu
August 30, 2006

Noting that the biotechnology industry in Asia is still at a nascent stage, India has announced the launch of an annual 'Asia Biotech' meet, bringing together scientists and biotechnology experts who will focus mostly on the needs of the people of the region.

"Most of Asia is largely an agricultural community so agricultural biotechnology is necessary for food security," Minister of Science and Technology Kapil Sibal said adding that the experts would also focus on health security.

The launching of the annual meeting was announced by Sibal at the fourth Asean informal ministerial meeting on Science and Technology, held at Kuatan in Pahang state.

The meet is modelled on the lines of the 'Biotechnology Conference' held annually in the United States. Next year's meeting will be held at Boston.

The Asia Biotech conference will be held in rotation across Asean plus six nations viz China, Japan, South Korea, India, Australia and New Zealand. The first conference will be held at New Delhi in November 2007.

Africa: Scientists, environmentalists want vitamin A rice

Here's an interesting article on the latest developments of a genetically modified rice to help people around the world with vitamin A deficiency.

Regards,
Alisa

Africa: Scientists, environmentalists want vitamin A rice
By Josephine Maseruka
All Africa
August 30, 2006

Scientists are working round the clock to develop the much needed acceptable rice variety with Vitamin A that can help the 400 million people in the world at risk of vitamin A deficiency.

The first African Rice Congress held in Dar es Salaam early August heard that between 100 and 200 million children are affected by severe vitamin A deficiency of whom 50 million are in Sub-Saharan Africa. Records also show that 1.3 million to 2.5 million pre-school children die annually because of vitamin A deficiency. In developing nations, where Uganda falls, vitamin A deficiency is responsible for 250,000 cases of blindness every year.

Vitamin A deficiency is also a leading cause of early child death, diarrhoea, measles, pneumonia and a major risk factor for pregnant and lactating women. The alarming situation has led to attempts by European scientists to develop rice varieties with vitamin A.

Dr. Ingo Portrykus, a professor of science at the Swiss Federal Institute of Technology and Peter Beyer of the University of Freeburg in Germany have developed the Golden Rice with high levels of Beta-carotene, which is converted to vitamin A in the body. Two genes were taken from a plant called daffodil and a third gene from bacterium which were introduced into rice through genetic engineering to get rice with vitamin A.

Dr. G.S. Khush of California University told the congress that the goal for the genetic engineering was to improve the rice nutritional content to fight the growing rate of malnutrition, especially among people who derive most of their calories from rice.

Khush said the invention was also aimed at lowering the risk degree of vitamin A deficiency and healthy problems that result from it.

The International Rice Research Institute Director P. Anderson said, 'Vitamin A is necessary for the poor. We cannot reach the very many of the malnourished in the world. Rice with vitamin A can be a suitable alternative.'

However, the Golden Rice has already met stiff resistance from scientists and environmentalists. They argue that 300gm of Golden Rice can provide at most 20% of adult's daily dose of vitamin A and since pre-school children consume less than 150gm of rice daily, Golden Rice would only supply a little 10% of the required vitamin A daily.

Others have reasoned that vitamin A can be obtained from liver, milk, butter, egg yolk, chicken, meat while Beta-carotene can be got from dark green vegetables, spinach, carrot, pumpkin and mango, which can be taken in small quantities.

There are already attempts to get vitamin A through orange sweet potatoes, which are affordable to small farmers and the rural poor.

Health experts argue that Golden Rice if taken by people who have rice as a staple food, could lead to excessive intake of vitamin A among those who do not suffer from vitamin A deficiency.

Excessive vitamin A can lead to hypervitaminosis or vitamin A toxicity which leads to abdominal pain, vomiting and dizziness. Daffodil is responsible for allergic reaction that manifests as a rash.

Environmentalists insist that they need proof that there are no serious environmental consequences to the ecology from the Golden Rice and that it won't have adverse effect or risk on people's health.

August 29, 2006

No biotech beans for you

Here's an interesting article I came across about some dramatic changes in Romania, a country that has accepted genetically modified foods and crops but will have to change once it joins the European Union in 2007.

Regards,
Alisa

No biotech beans for you
By Gil Gullickson
Agriculture Online
August 29, 2006

Imagine how you'd feel if you suddenly had to go back to planting conventional soybeans because you could not plant glyphosate-tolerant soybeans.

Well, that's the situation farmers in Romania are in. This southeastern European country is slated to join the European Union (EU) on Jan. 1, 2007. When it does, farmers won't be able to plant biotechnology crops, such as Roundup Ready soybeans.

As in the United States, a vast majority of soybeans raised in Romania are glyphosate-tolerant. For example, Romanian farmers planted 85,000 hectares (210,035 acres) of Roundup Ready soybeans in 2005. However, EU mandates will prevent these farmers from raising them in 2007 when Romania joins the EU.

"Overall reaction (by the Romanian public) is positive for joining the EU, but farmers are afraid," says Cristina Cionga, agricultural specialist with the USDA Foreign Agricultural Service in Bucharest and a Romanian native.

We recently visited with Cionga and three fellow Romanian agricultural scientists and their host, Paul Weller, president of Agri/Washington, Washington, D.C. One of the reasons the group is touring the United States is to give farmers back in Romania ideas on how U.S. farmers have communicated benefits of raising biotech crops to the general public and policy makers.

Like U.S., farmers, Romanian farmers readily accepted biotech crops. "They love the technology," says Cionga.

Herbicide-tolerant soybeans were first brought to Romania in 1999 and controlled severe weed problems in soybeans that existed before that time. Without access to glyphosate-tolerant soybeans, Romanian farmers will be stymied when it comes to growing soybeans in 2007.

They aren't giving up, though. A group of the nation's largest soybean growers are organizing and lobbying to gain provisional authority from the EU to grow them. Although it may be too late to grow them in 2007, the group that visited with us is hopeful provisional authority may be granted in 2008.

One of the points the Romanian visitors hope to gain from their visit is how U.S. commodity groups work. The visitors are especially enthralled by commodity checkoffs and how agribusiness supports commodity groups and farmers.

"We've learned about the resources that are available and how commodity groups communicate to the public about biotechnology," says Cionga.

The Romanians will take what they have learned in the U.S. to give Romanian farmers an idea how to rally support for biotech crops. "These farmers are credible and they would be believed," says Cionga.

Romanian agriculture

Besides soybeans, Romanian farmers raise even more corn and wheat. Romanian farmland is excellent, with rich, black soils.

Romanians are interested in biofuels, as some biodiesel plants have been built in the country. Ironically, biotech beans can be imported and crushed at these plants, but Cionga and Weller pointed out that farmers will not be able to grow them when Romania joins the EU. There are no ethanol plants on line to consume the nation's corn.

Like other countries in Eastern Europe, Romania has undergone a transformation since agriculture was decentralized in 1989.

"We started from scratch learning about markets," says Cionga. "All state units were dismantled and land went back to previous owners and their heirs. Even now, there are trials in court fighting over land. Property rights are not fully enforced."

The nation's largest farmers are a lot like U.S. farmers in that they rent a much of their land. "These farmers will own about 10% of what they farm, and lease the rest," says Cionga.

Therapeutic proteins from GE tobacco plants: Chlorogen gets lucky in Kentucky

Here's a great article on a collaboration on a new therapeutic proten made from genetically modified tobacco plants.

Alisa

Therapeutic proteins from GE tobacco plants: Chlorogen gets lucky in Kentucky
By Rachel Melcer
St. Louis Post-Dispatch
August 29, 2006

David Duncan, chief executive of Chlorogen Inc., said a fortuitous turn of events brought his company a partner that could shave years off the development of an ovarian cancer drug.

Chlorogen, based in Creve Coeur, has genetically engineered tobacco plants to grow a therapeutic protein -- and had planned to build a plant in Cape Girardeau to extract and purify it. But a new company, Kentucky Bioprocessing LLC, or KBP, was formed in March around a plant-based protein processing facility in Owensboro, Ky., it bought from bankrupt Large Scale Biology Corp.

KBP's contract processing capabilities and expertise are a perfect fit for Chlorogen, Duncan said. With its help, Chlorogen could save a year or two in product development -- along with $4 million it would have invested in an $18 million facility at Southeast Missouri State University in Cape Girardeau.

"It was extremely fortuitous," Duncan said. "Very rarely do you get lucky in this business, but we (did)."

The success of Chlorogen, a company at the cutting edge of the fledgling "biopharming" industry that genetically modifies plants to produce useful proteins, is good for Missouri, say economic development officials.

But Chlorogen's good luck is bad news for Southeast Missouri State, which had looked forward to being the company's processing base, said Mike Mills, deputy director of the Department of Economic Development.

The Chlorogen facility would have anchored a research center listed among projects for funding through Gov. Matt Blunt's Lewis and Clark Discovery Initiative. The initiative -- which would use proceeds from the sale of assets of Missouri's student loan authority to fund capital research and commercialization projects at state universities -- stalled in the Legislature in March. Blunt's plan to revive it was revealed Saturday.

If Southeast Missouri State goes ahead with construction, Chlorogen might put its facility to limited use, Duncan said. But his venture capital-backed startup can't justify investing time and money in a new plant when the KBP alternative is available.

KBP, a subsidiary of Owensboro Medical Health System, was formed to develop drugs while contributing to that region's economy. It is part of a Kentucky focus on finding alternative uses for its large tobacco crop, Duncan said.

"That is a major strategic thrust" that fits well with Chlorogen's business, he said. "Nothing against Missouri, but Kentucky just had that going for it."

Chlorogen will remain a Missouri-based company, and continue to use greenhouses at the University of Missouri's Delta Research Center in Portageville to grow crops, Duncan said.

But those tobacco plants will be shipped to KBP. If the research collaboration goes well, KBP will conduct Chlorogen's protein extraction, purification and development into a marketable drug, he said.

"The hope is that we'd get to that point," Duncan said. Early-stage work already under way "is where we find out if they've got the capability that we think they do. We'll put that to the test."

KBP's relationship with Brown Cancer Center in Louisville also could lead Chlorogen to conduct clinical trials there, augmenting a deal the firm has with St. Louis University School of Medicine, Duncan said.

Hugh Haydon, chairman of KBP, said his company includes former employees of Large Scale Biology, biopharming pioneers who developed the processing plant. He believes it is the only facility and team in the world that has produced plant-made proteins for commercial sale.

Large Scale Biology couldn't afford the high cost of drug development. KBP is a contract manufacturer, with no products of its own.

"We've done a lot of different kinds of projects in a lot of different kinds of plants," Haydon said, but he would not reveal other clients.

With Chlorogen, "we are very excited about the opportunity that the relationship has," he said. "We appreciate their confidence and we hope that we can help them to succeed -- because If we do that, we succeed, too."

August 27, 2006

Legislation would allow gene-modified seeds

Here's a good article about the latest developments over genetically modified foods in California.

Alisa

Legislation would allow gene-modified seeds
San Jose Mercury News
August 26, 2006

A bill that would prevent local governments from banning genetically modified seeds is one step away from Gov. Arnold Schwarzenegger's desk after passing both houses of the Legislature with bipartisan support.

Senate Bill 1056 by Sen. Dean Florez, D-Bakersfield, would place seed regulation under the exclusive control of the state.

Four counties -- Marin, Mendocino, Trinity and Santa Cruz -- have established bans on bio-engineered crops and would be exempt from the bill.

Opponents of genetically engineered food say its potential health and environmental effects have not been adequately studied.

Supporters of Florez's bill say existing state and federal laws already provide adequate oversight of genetically modified crops.

August 26, 2006

Genetically modified crops get tentative support

Here's an good article regarding the support of biotechnology in Oregon.

Alisa

Genetically modified crops get tentative support
Oregon News Review
August 25, 2006

The future of biopharming in Oregon may fall under state regulation instead of federal oversight if the recommendations of a committee on genetically modified crops are followed.

Regulation of biopharming crops, like other genetically modified organisms, falls to an arm of the U.S. Department of Agriculture. State agricultural officials are given notice of permit applications for field trials but have no authority over them.

A failed bill in the 2005 Legislature sought a four-year state moratorium on biopharming, which involves growing crops with genes that have been altered to create pharmaceuticals.

No such crops are currently under cultivation in Oregon but field trials in other states have provoked debate over the risks and benefits.

A 10-member committee, composed of state agricultural and health officials and scientists, was created last year and has been meeting monthly since November.

On Thursday, it released the recommendations for public comment. Members will meet in late September, then make a final report to Gov. Ted Kulongoski.

The committee said research and production of plants that yield medicines should be encouraged, provided that the state can exercise more controls to protect conventional crops and public health.

Benefits include the potential for large-scale production of medications at low cost and introduction of vaccines into food crops. However, opponents fear the modified crops could contaminate food supplies or provoke allergic reactions through pollen.

Steve Strauss, an Oregon State University forestry professor and authority on genetic tree engineering, is one of the committee’s members. He said biopharming holds great potential for public benefit, but the state needs to have a bigger role.

“Unless some clear process is in place, we don’t want to see pharmaceuticals out of doors in food crops,” he said.

The recommendations of the committee include:

— Encourage biopharming as a possible area of investment in technology. The state’s mild growing season and established greenhouse and nursery industry give it competitive advantage over other states.

— Formalize an agreement with the USDA over regulating such crops, including allowing veto rights to state officials.

— If biopharming crops are grown outdoors, encourage that they not be consumed by humans or animals. Also, require posting of a financial guarantee in case of crop contamination or human exposure.

The committee's recommendations can be found at: http://oregon.gov/ODA/PLANT/biopharm.shtml.

August 25, 2006

Pharmaceuticals from plants

Here's a very interesting article on how biotechnology is aiding in the development of pharmaceuticals.

Alisa

Pharmaceuticals from plants
By Sushmi Dey
Indian Express Newspapers (Mumbai) Limited via Express Pharma
August 25, 2006

Advances in biotechnology aided in the production of therapeutic proteins essential in a wide range of pharmaeuticals like monoclonal antibodies, enzymes and blood proteins.

Since the demand for these biopharmaceuticals is expected to increase, researchers all over the world are looking at ways to ensure that they will be available at significantly larger amounts and on a cost-effective basis. One such solution comes in the form of plant-made pharmaceuticals (PMPs), which are cheap to produce and store, easy to scale up for mass production and safer than those derived from animals.

The plus factor

The use of plants for medicinal purpose dates back to thousands of years, but genetic engineering of plants to produce desired biopharmaceuticals is a much more recent phenomenon. In normal circumstances, drugs are synthesised through strong chemical reactions or taken from natural sources such as texol or curcumin. The conventional system in place for the production of commercial protein has relied on microbial fermentation and mammalian cell lines. But according to studies, these systems have disadvantages in terms of cost, scalability, and safety that have promoted research into alternatives.

PMPs are a category of pharmaceutical proteins that are produced in 'live plants'. These live plants are genetically modified to produce drugs. "Plants can produce large amount of proteins in them," says Dr V Siva Reddy, Group Leader, Plant Transformation Group, ICGEB. Plants can express a protein in a very profitable manner by manipulation of genes or by the introduction of genes required to express a particular protein. Hence, pharmaceuticals can be produced in large quantity, and purity can be expressed in high levels.

Plants have emerged as one of the most promising general production platform for biologics. Plants allow cost-effective production of recombinant proteins on an agricultural scale, while eliminating risks of product contamination with endotoxins or human pathogens. In addition, with the use of plants in the production of recombinant protein, vaccine candidates can be expressed in edible plant organs, allowing them to be administered as unprocessed or partially processed material. However, in matters of efficacy, they are equivalent to the conventional drugs, informs Reddy.

Technology behind PMPs

In the process of producing PMPs, plants themselves act as factories to manufacture therapeutic proteins. Special proteins or compounds are expressed in different parts of plants, some specific tissues, such as whole leaves, whole seeds, or even specific regions of seeds or leaves. The whole process is meant to incorporate the desired foreign gene into the genome of the plant to create a transgenic plant. "It is preferred to produce those pharmaceuticals, which are protein, carbohydrate or lipid based, specifically those which can be expressed and stored in roots, seeds or small inclusion bodies in the cell," explains the Director of Department of Biotechnology (DBT). After the plants are harvested, they go through a series of processing steps that extract, separate, purify and package the therapeutic proteins.

The production of the desired protein in a plant requires a number of complicated molecular biology techniques, where the propriety promoter is fused to the gene of the target protein, forming an expression cassette. With these transgenic techniques, the proprietary expression cassette is introduced into plant cells. The transformed cells are then cultured as suspension cells or regenerated as transgenic plants. High protein expressers are selected and used for protein production. The refined therapeutic proteins are ultimately used as active pharmaceutical ingredients (APIs) in many life-saving medicines and are regulated by the FDA.

In PMPs, plants are the factory or storehouse, where proteins, that will be used in subsequent manufacture of medicines, as the API in a pharmaceutical product, are produced. The normal techniques of extraction, purification and formulation, which are used in normal pharmaceutical companies, are all followed even in the case of PMPs. Though therapeutic proteins produced in PMP field trials are usually not intended to be administered via food, some of the PMPs can be taken orally, while some have to be injected.

Production platforms

There are several plant-based protein production platforms that rely on protein expression from nuclear genes and viral vectors in leaf, seed, tuber and tissue culture cells. However, each of the platforms has its own strengths and weaknesses. Crops such as corn, tobacco, rice, soy, wheat, barley and maize are genetically altered to yield proteins in different parts of the plant. Scientists prefer to opt for genetically modified food crops because of the good understanding of genetics, agronomics and environmental impact of the crops.

Leafy crops are advantageous in terms of biomass yield, but since proteins expressed in such leaves tends to be unstable, the harvested material has a limited shelf life and therefore, must be processed immediately after harvest. However, proteins that are expressed in cereal seeds are protected from proteolytic degradation. Hence, such proteins can be preserved for three years at room temperature and for at least three years at refrigerator temperature without much loss of activity. Prodigene, an industry leader in cereal based protein production has chosen Maize because of its high biomass yield.

Yet another plant group which is considered as good hosts for protein production are oil crops, as oil bodies can be exploited to simplify protein isolation. As per published records, SemBioSys Genetics has developed oleosin-fusion platform, in which the target recombinant protein is produced in oilseed rape as a fusion with oleosin. The Finnish biotech company, Unicrop is also developing an oil seed platform. However, they are attempting to isolate recombinant proteins from rapidly developing sprouts cultivated in bioreactors.

Tobacco helps

Surprisingly, tobacco forms a well-established expression host for which robust transformation procedures are available. Tobacco has a high biomass yield and rapid scalability which makes it a popular choice for commercial molecular farming. "Tobacco is also preferred since it is not a food or feed crop and hence carries reduced fear for transgenic material or recombinant proteins contaminating feed and human food chain," explains Reddy. However, the high content of nicotine and other toxic alkaloids, which are harmful, need to be completely removed during downstream processing steps. Tobacco, as a platform, has also been adopted by several biotech companies, across the world. According to the latest published records, Planet Bio-technology and Meristem Therapeutics are companies who have PMPs with tobacco as a platform with products in Phase II clinical trials.

In the future

Stunning advances in areas of immunology, genomics and molecular screening have dramatically increased the hope for PMPs in the pipeline. But the truth is that the pipeline is not flowing as smoothly as it should because of the daunting costs of building adequate production facilities. "Any new technology is expensive in the beginning but with increase in volumes, competition and time, the price will come down," opines Reddy. Agrees the Director from DBT, "Once the procedures are standardised and streamlined, PMPs can be very cost-effective," she says. She also feels that there is a good potential in the technology but in India, it is not being taken up in an aggressive manner as it has been done in US and France. However, the industry is still optimistic about it.

Researchers believe that one of the keys to success will be the level of expression of the recombinant protein in plants. The expression level will affect the cost of growing, processing, extraction, purification and waste disposal.

Fast-growing GM trees could take root as future energy source

Here's an great article on how genetically modified trees may help in the future as a energy source.

Alisa

Fast-growing GM trees could take root as future energy source
YubaNet
August 25, 2006

tree that can reach 90 feet in six years and be grown as a row crop on fallow farmland could represent a major replacement for fossil fuels.

Purdue University researchers are using genetic tools in an effort to design trees that readily and inexpensively can yield the substances needed to produce alternative transportation fuel. The scientists are focused on a compound in cell walls called lignin that contributes to plants' structural strength, but which hinders extraction of cellulose. Cellulose is the sugar-containing component needed to make the alternative fuel ethanol.

The Department of Energy's Office of Biological and Environmental Research is funding a $1.4 million, three-year study by Purdue faculty members Clint Chapple, Richard Meilan and Michael Ladisch to determine ways to alter lignin and test whether the genetic changes affect the quality of plants used to produce biofuels. A hybrid poplar tree is the basis for the research that is part of the DOE's goal to replace 30 percent of the fossil fuel used annually in the United States for transportation with biofuels by 2030.

In 2005 ethanol accounted for only 4 billion gallons of the 140 billion gallons of U.S. transportation fuel used - less than 3 percent. About 13 percent of the nation's corn crop was used for that production. Purdue scientists and experts at the U.S. departments of Agriculture and Energy say corn can only be part of the solution to the problem of replacing fossil fuel.

"If Indiana wants to support only corn-based ethanol production, we would have to import corn," said Chapple, a biochemist. "What we need is a whole set of plants that are well-adapted to particular growing regions and have high levels of productivity for use in biofuel production."

Chapple and Meilan want to genetically modify the hybrid poplar so that lignin will not impede the release of cellulose for degradation into fermentable sugars, which then can be converted to ethanol. The changed lignin also may be useable either in fuel or other products, they said. Currently about 25 percent of the material in plants is the complex molecule lignin, which in its present form could be burned to supply energy for ethanol production, but cannot be transformed into the alternative fuel.

Altering lignin's composition or minimizing the amount present in a cell wall could improve access of enzymes. With easier access, enzymes would be able to more efficiently convert cellulose to sugars. Current treatments used for extracting lignin from woody products for pulp and paper production are harsh and pollute the environment, said Meilan, a Purdue Department of Forestry and Natural Resources molecular tree physiologist.

To advance production of non-fossil fuels, Chapple and Meilan are using genetic tools to modify the poplar and then study how the alterations changed the plants' cell walls. Meilan also is attempting to find ways to produce trees that are reproductively sterile so they are unable to transfer introduced traits to wild trees.

When Chapple and Meilan are satisfied with the results, they will give wood samples to Ladisch, a distinguished professor of agricultural and biological engineering, so he can determine if the changes have created trees suitable for high-yield ethanol production.

Using hybrid poplar and its relatives as the basis for biofuels has a number of advantages for the environment, farmers and the economy, they said.

"Poplar is a low-maintenance crop; plant it and wait seven years to harvest it," Meilan said. "You're not applying pesticides every year; you're not trampling all over the site every year and compacting the soil. You're allowing nutrients to recycle every year when the leaves fall and degrade. In addition, you are more likely to have greater wildlife diversity in poplar plantings than in agricultural fields."

Experts are proposing planting the trees in rows just like any field crop. The basis of these tree plantations will be tens of millions of acres that the DOE and USDA have inventoried as being unused or fallow - previously used farmland that is standing empty because farmers are paid not to grow anything.

"We need a bioenergy crop that can grow many places year-round," Meilan said. "The genus Populus includes about 30 species that grow across a wide climatic range from the subtropics in Florida to sub-alpine areas in Alaska, northern Canada and Europe."

Corn can be grown only in a few areas of the world and only during a relatively short growing season. Besides needing potential fuel-source crops that can be grown year-round and in many geographical locations, experts also want to increase the per acre tonnage yield of crops and the gallons of ethanol per ton.

Researchers believe that using the hybrid poplar in its present form could produce about 70 gallons of fuel per ton of wood. Approximately 10 tons of poplar could be grown per acre annually, representing 700 gallons of ethanol. Corn currently produces about 4.5 tons per acre per year with a yield of about 400 gallons of ethanol. Changing the lignin composition could increase the annual yield to 1,000 gallons of ethanol per acre, according to experts. Planted on 110 million acres of unused farmland, this could replace 80 percent of the transportation fossil fuel consumed in the United States each year.

"We don't want to compromise the structural integrity of the plant," Meilan said. "We just want to alter the lignin composition to make it easier to liberate the cellulose for conversion to simple sugars that the yeast can gobble up and turn into ethanol."

Chapple and Meilan are affiliated with the Energy Center and the Bindley Bioscience Center at Purdue's Discovery Park. Meilan also is affiliated with the Hardwood Tree Improvement and Regeneration Center. Ladisch is director of Laboratory of Renewable Resources Engineering (LORRE).

Purdue's Discovery Park is designed to bring together researchers from a wide range of specialties and provide an environment for interdisciplinary research that explores new ideas, technologies and moves research to the marketplace. It is now a $300 million enterprise with 10 established research centers.

Purdue and U.S. Sen. Richard G. Lugar (R-Ind.) are co-sponsoring the Summit on Energy Security on Aug. 29 on the West Lafayette campus. Among the participants scheduled are Indiana Gov. Mitch Daniels, Ford Motor Company's vice president for the environment and safety, Susan Cischke, and Peggy Hudson, U.S. vice president for federal and international affairs for fuel giant BP America Inc.

USDA says validated Bayer test for GMO rice

Here's an interesting article about a recent test developed in response to recent questions over an unauthorized genetically modified rice strain that was found in commercial rice.

Alisa

USDA says validated Bayer test for GMO rice
By Christopher Doering
Reuters
August 25, 2006

U.S. government scientists certified a test by Bayer CropScience on Thursday that detects when an unapproved genetically modified rice has been mixed into commercial rice, the Agriculture Department said.

A number of customers for U.S.-grown rice have said they will demand tests for the gene. While a small rice grower, the United States is one of the world's largest exporters, sending half of its crop to foreign buyers.

Federal and industry officials said they do not know how much of the U.S. rice stockpile contained the gene or if this year's crop, nearing maturity, was affected.

"I can guarantee that there will be very extensive testing especially now that we have validated or certified the testing for 601," said Agriculture Secretary Mike Johanns, referring to the experimental LL Rice 601 strain.

USDA's Grain Inspection, Packers & Stockyards Administration began working with Bayer CropScience, a unit of Bayer AG (BAYG.DE: Quote, Profile, Research), about two weeks ago after U.S. agriculture and food safety authorities learned on July 31 that Bayer's unapproved rice had been found in commercial bins in Arkansas and Missouri.

The genetically engineered long grain rice has a protein known as Liberty Link, which allows the crop to withstand applications of an herbicide used to kill weeds.

GIPSA used reference material and methodology provided by Bayer CropScience to verify the company's ability to distinguish its strain.

"We verified a 601 method back to Bayer," said Steven Tanner, director of GIPSA's Kansas City laboratory where the test verification work was conducted.

Tanner said the lab was doing "some additional confirmations on components" but Bayer was now able to take its test to commercial laboratories.

Bayer officials have said they are working to get six labs ready to begin commercial testing. The company predicted on Thursday that tests could begin in a matter of days.

Quentin Schultz, president of BioDiagnostics Inc. whose company would help conduct the tests, said he has already received samples from seed companies and grain processors. The labs must first show they can comply with testing protocols from Bayer.

"As soon as we get a go from (Bayer) we're going to start because we've got samples in here already," Schultz said.

He estimated his company could process as many as 100 tests each day, with each test taking between 48 and 72 hours.

The European Commission on Wednesday said the EU would require imports of U.S. long grain rice to be certified as free from the unauthorized strain. The commission said validated tests must be done by an accredited laboratory and be accompanied by a certificate. Japan, the largest importer of U.S. rice, has suspended imports of U.S. long-grain rice.

USDA and the Food and Drug Administration have said there is no public health or environmental risk with the genetically engineered rice.

USA Rice Federation, which markets and promotes U.S. rice, has opposed the commercialization of genetically modified rice until it has gained wider consumer acceptance. David Coia, a spokesman for the group, said the test is a necessary step to reassure buyers of U.S. rice.

"If other markets are requiring the certification then certainly the test will be available," said Coia. "In the end, yes, it should help."

The United States is expected to produce a rice crop valued at $1.88 billion in 2006. U.S. rice growers are responsible for about 12 percent of world rice trade. Three-fourths of the crop is long grain rice, grown almost entirely in the lower Mississippi Valley. California, the No. 2 rice state, grows short grain rice.

Insulin from plants will meet demand

Here's an interesting article on how genetically modified crops are needed in the production of insulin to meet global demands.

Alisa

Insulin from plants will meet demand
Sydney Morning Herald
August 24, 2006

Insulin must be grown in genetically engineered plants to meet fast-growing demand created by the global diabetes epidemic, an Australian conference has been told.

More than seven per cent of Australians have type two diabetes, with up to 40 per cent relying on regular insulin injections to control blood sugar levels.

Until the mid-1980s, insulin was animal derived, but with the advent of biotechnology most of the world's supply is now produced through fermentation of bacteria in laboratories.

But Canadian biopharmaceuticals expert Professor Maurice Moloney has told the International Congress of Plant Molecular Biology in Adelaide that the costs of production were enormous and fast-growing.

The number of people with type two diabetes, also know as the lifestyle disease, was expected to increase to 300 million within 20 years.

Those suffering the lesser virulent type one diabetes are entirely dependent on insulin injections.

Prof Moloney, founder of SemBioSys Genetics, said genetically engineered plants offered a cheap, abundant and viable source of insulin.

"The capital required to produce the required amount of insulin from other sources runs into billions of dollars," he said.

"To produce it from plants would be about one tenth of that cost.

"And what's more, it would not require millions of hectares (because) world supply could be produced from two average sized farms."

Prof Moloney said purified insulin could be authentically produced from proteins in genetically engineered plant seeds to be identical to insulin produced in the pancreas of healthy people.

Research facilities were working to create safe technology to produce insulin in oil seed plants, such as safflower.

He said there was intense rivalry among companies around the world to prove the area could provide an unprecedented scale of production and storage flexibility.

The process required extensive agricultural controls and there were challenges in navigating the pharmaceutical approval system through clinical trials for safety and effectiveness, Prof Moloney said.

"However, the capability exists and one example of clinical success will transform the insulin production industry, and indeed the production of other pharmaceuticals," the scientist said.

August 24, 2006

Agricultural Biotechnology is Beneficial to Smallholder Farmers

Here's an interesting piece from a fellow blogger about how agricultural biotechnology has been helping smallholder farmers in South Africa. Hope you find it very informative.

Best,
Alisa

Agricultural Biotechnology is Beneficial to Smallholder Farmers
by James Wachai
AgBioView & GMO Africa
August 23, 2006

Anti-biotech activists are fond of casting genetically modified (GM) crops as a domain for stinking-rich farmers. They have vainly tried to ingrain in the minds of many that smallholder farmers have nothing to gain from GM crops cultivation.

But a research published last month by Marnus Gouse and Johann Kirsten, both of the University of Pretoria, South Africa, Carl Pray (Rutgers University, U.S.A.), and David Schimmelpfennig (United States Department of Agriculture Research Service), showed that smallholder farmers in South Africa have benefited from genetically modified maize cultivation, just like their large-scale counterparts.

Last week, Mexican researchers published yet another study that will further reinforce the argument that agricultural biotechnology is geared towards poor-resource farmers.

Octavio Guerrero-Andrade of the Center for Research and Advanced Studies (CINVESTAV) in Guanajuato and colleagues, in their article in the online edition of Transgenic Research, explain that a gene from the Newcastle disease virus will be inserted into maize DNA. Chicken that eat the genetically modified maize will produce antibodies against the Newcastle disease virus.

There is no doubt that this new maize variety will be a big boon to poultry farmers, especially in developing countries. They will no longer worry about expensive vaccines.

Poultry farming is a common practice in many developing countries. In many rural areas, whole families derive their livelihood from poultry farming. In countries such as Nigeria and South Africa, poultry farming plays an integral role in national development.

This new genetically modified maize, inarguable, will be the most effective and convenient tool to control the Newcastle disease. The existing vaccines for New Castle disease are out of reach of poor farmers. These farmers live on less than a dollar a day. Such income will be hardly enough to buy vaccines. Moreover, such vaccines require refrigeration, yet electricity is non-existent in most rural areas.

Farmers in developing countries must go for the new genetically modified maize. It will definitely boost their income.

To learn more about GMO Africa, go to http://gmoafrica.org/index.html

August 23, 2006

Flavonoid-rich GM tomatoes could boost heart health

Here's a great artice on how genetically modified tomatoes can boost heart health. Hope you find it informative.

Alisa

Flavonoid-rich GM tomatoes could boost heart health
By Stephen Daniells
Food Navigator
August 23, 2006

Tomatoes genetically modified to have high flavonoid content could reduce the levels of a protein in a mouse that is associated with inflammation, diabetes and heart disease in humans, says a study by BASF, TNO and two universities in Holland and Germany.

“This is the first time that specific fruit has been demonstrated to reduce human C-reactive protein (CRP) and that transgenic over-expression of specific flavonoids results in a further reduction of this important cardiovascular risk marker,” wrote lead author Dietrich Rein from BASF Plant Science Holding GmbH.

A number of genetically modified plants and crops are coming to light with enhanced nutritional content considered to offer human health benefits, including zeaxanthin to potato tubers, and the omega-3 fatty acid, eicosapentaeoic acid (EPA), to soybeans, brassica, and stearidonic acid (SDA) in canola crops.

However, no GM crops with potentially enhanced health benefits have been approved for human consumption, and consumer acceptance, particularly in Europe, and most notably in the UK, continues to be one of the biggest challenges for these crops.

And by feeding the peel of transgenic tomatoes to mice genetically engineered to express human CRP, the researchers report that this enables them to putatively study the potential human health effects of these flavonoid-enriched tomatoes (flTom).

CRP is produced in the liver and is a known marker for inflammation. Increased levels of CRP are a good predictor for the onset of both type-2 diabetes and cardiovascular disease.

Rein and his associates, writing in the September issue of the Journal of Nutrition, report that feeding the CRP mice with a diet supplemented with four grams per kilogram of flTom peel, wild-type tomato (wtTom) or a control. The amount of tomato fed to the mice is equivalent to a human daily intake of 2.3 grams of peel or about 230 grams of fresh tomato.

This, said the researchers, “constitutes a portion that is achievable in the human diet.”

After seven weeks of feeding the respective diets, Rein and his co-workers measured levels of general health and cardiovascular risk, such as plasma CRP, and cholesterol levels.

It was found that consumption of either tomato peels was associated with a significant decrease in levels of human CRP, with flTom “significantly exceeding” the effect of wtTom (56 versus 43 per cent reductions, respectively).

Levels of HDL-cholesterol, so-called ‘good' cholesterol, were also up in both tomato groups.

The levels of CRP in the flTom-fed mice were found to have increased back to baseline levels after a two week washout period.

“To our knowledge, results from this study demonstrate for the first time that a genetically engineered fruit with enhanced flavonoids levels can have anti-inflammatory effects that exceed the effects of its wild-type counterpart,” wrote the researchers.

To increase the flavonoid content in the tomato the Dutch and German researchers inserted Petunia chalcone isomerase (CHI) and Gerbera hybrida flavone synthase (FNS) genes into tomato plants to obtain the final transgenic plant, Lycopersicon esculentum cv. Moneymaker.

Since the skin of the tomatoes contain more than 95 per cent of the flavonoids, the researchers used the peel of this flavonoid-enriched tomato (flTom) to feed to mice that express human CRP.

The flTom contained significantly higher concentrations of the flavonoles, quercitin and kampferol, and their respective glucosides and rutinosides, and the flavone, luteolin (aglycon and glucoside derivatives) than the normal wild-type tomato (wtTom).

And it is the effect of these flavonoids, propose the researchers, on the signalling of the so-called nuclear factor-kappa B(NF-kB), a pro-inflammatory protein that is also said to activate a variety of human cancers, that could be behind the benefits.

“Flavanols and flavones exert anti-inflammatory activities on NF-kB-regulated genes,” they said. Despite such positive results in the mouse model with human CRP, Rein wrote that it remained unclear whether similar results would be obtained in humans as a consequence of eating flavonoid-enriched tomatoes.

However, “genetic enhancement of valuable dietary components in plant foods, such as specific flavonoids in tomatoes, may allow us to reduce the burden of cardiovascular disease,” he concluded.

Science for food

Here's an interesting commentary I came across regarding GM foods in Southern Africa.

Alisa

Science for food
By Mzati Nkolokosa
The Nation (Malawi) via AgBios
August 23, 2006

The famine of 2001 was a double-edged sword in Southern Africa and Malawi was a typical example.

On one side, people were dying of hunger-related illnesses. On the other, government was being accused of accepting genetically modified (GM) relief maize.

Zambia, which was starving as well, was praised for rejecting GM maize because as Mwananyada Lewanika, a biochemist at the Institute for Science and Technology said “GM maize is risky to people.”

This was bought by a network of international organisations. Here, the Malawi Economic Justice Network (MEJN) brought 10 African countries to a conference where GM foods were condemned, saying people were supposed to be warned of the dangers of consuming such foods and that Malawi was supposed to reject the maize.

Government was compelled to mill the maize to prevent people from planting the seed because, as people speculated, GM maize had the ability to kill other crops.

But GM crops are not that bad as I discovered on a fact finding mission in South Africa where I went about the country, visiting GM maize and cotton farmers. In fact, the right name is genetically improved (GI) or biotechnology—applied biology that uses any living system to produce something useful using the latest tools and techniques.

“Science is for the benefit of people,” said Professor Diran Makinde of AfricaBio, an independent, non-profit biotechnology stakeholders association whose role is to provide accurate information and create awareness on biotechnology in South Africa and the region. “A scientist cannot give people something that will destroy them. That is not science.”

Makinde was speaking when he introduced biotechnology to parliamentarians, journalists and scientists from Malawi and Kenya.

The audience was all silent, marvelling at the presentation. Biotechnology, said Makinde, is the science of improving crops and animals by taking genes from any source into another organism.

This technology, although known to most Malawians a couple of years ago, has been around for decades and been useful in sewerage and compositing, making of bread, wine, beer, medicinal plants and vaccine.

A typical example is medicinal trees.

If a medicinal tree in North Pole cannot grow in Malawi, scientists can take the genes to a specie in Malawi, put that gene in a miombo, to produce the same effect as the medicinal tree of the North Pole. That is how biotechnology works.

That is what scientists have done with maize and cotton, for example. It is working in South Africa, the continent’s only country growing GM crops at commercial level.

In Soweto I met a group of women growing BT maize. Their field trials were educative. One of them, Ella Baloyi, was speaking reasonable Chichewa.

“Amuna anga anali a ku Malawi [My husband was from Malawi],” she said. “Look up for him [name withheld] in Lilongwe. He left three years ago.”

She talked of how BT maize is helping them, commercially. She belongs to a club that planted BT maize on one plot and non-BT maize on another. Both were mature and dry.

But there was difference. BT maize cobs were big and healthy, not attacked by insects while non-BT maize cobs were small and partly suffering from weevils and such other insects.

This means more maize has been harvested from a BT crop than non-BT crop from two identical plots. And the differences are remarkable, huge that one wouldn’t go for non-BT maize once they try BT crop.

But it is at Makhathini in Kwazulu Natal where the power of BT crops manifests itself. The place is hot, like Malawi’s lakeshore, typical of cotton growing areas. Farmers here have been growing cotton for years.

But once they tried BT cotton, they vowed never to look back to non-BT cotton.

“I don’t think I will ever grow non BT cotton,” said Rejoice Mkhabela, a farmer at Makhathini where a club of farmers is growing cotton. “With non-BT cotton we used to spray every week for three months, now we spray four times.”

This is possible because BT cotton is a combination of genes that, among other things, make grow leaves that scare insects.

So is maize. Biotechnology is able to produce insect and drought resistant yet nutritious maize.

“Food biotechnology is a way to improve food, crops and animals by selectively giving plants and animals new qualities, such as more vitamins and minerals and better nutritional value.

Traditional breeding methods combine thousands of traits from two plants while with biotechnology, only the desired characteristic is added to a plant.

This means food may be enhanced to contain additional nutrients or other traits to make them taste fresh. Farmers also benefit by having new ways to fight pests and disease and grow food in a more environmentally friendly way.

BT farming is working in South Africa. President Thabo Mbeki has got biotechnology right.

He says his government will increase funding for agricultural research to promote the continuous improvement in competitiveness and leadership in ...biotechnology that is vital to South Africa’s agriculture.

This fired up the fact finding mission. Journalists and MPs realised “we were cheated that GM foods are bad when in true sense they are meant to end hunger in our countries”.

Malawi, too, was ready. Former Deputy Minister of Agriculture Henry Mumba said so. The country has a Biosafety Act to ensure safety imported of BT foods.

Our immediate enemy is not the Israel-Hizbollah war in Lebanon but hunger, disease and envy as the national anthem rightly suggests.

One African, Cryrus Ndiritu, has understood Mbeki correctly.

“It is not multinationals that have a stranglehold on Africa. It is hunger, poverty and deprivation. And if Africa is going to get out of that, it has got to embrace GM technology,” says Ndiritu.

Genetically altered cattle - what's at stake?

Here's an interesting article on discussions at the recent Agriculture Biotechnology Conference in Melbourne, Australia.

Regards,
Alisa

Genetically altered cattle - what's at stake?
By Ros White
Yorke Peninsula Country Times
August 22, 2006

Some of the world's foremost experts on agricultural biotechnology attended the Agricultural Biotechnology Conference in Melbourne, August 7-9.

Topics included the use of genes to improve crops, livestock cloning and reproduction, and the role of agricultural biotechnology in helping the environment.

A key speaker from the US was Dr Robert Wall, whose area of expertise is the introduction of new genes into animals as a means of improving livestock production efficiency.

CSIRO takes a stake

At the conference, CSIRO, which has been at the forefront of cattle-gene research for more than 10 years, announced it had taken an equity stake in Genetic Solutions, a global leader in the commercialisation for gene technology for the beef industry. The company has pioneered live DNA tests for beef eating qualities and a DNA test which provides paddock to plate traceability for the beef industry.

CSIRO Commercialisation GM Jan Bingley said, within the next five years, groups of 50 or more DNA markers will be available for the cattle industry.

Completed genome

The ability to improve health and disease management of cattle received a major boost with the release last week of the most complete sequence of the cow genome ever assembled.

Developed by an international consortium including the CSIRO, the new bovine sequence contains 2.9 billion DNA base pairs and incorporates one-third more data than earlier versions.

CSIRO's Dr Brian Dalrymple said, "We can use this data to identify those genes that are involved in important functions like lactation, reproduction, growth rate and disease resistance.

"This is just the beginning of a revolution in the way we produce our animals and food."

Beefing it up

Commercial tests are now available to identify tenderness and marbling in beef, using laboratory analysis of an animal's DNA, which can be extracted from tail hair roots.

The tests were developed by a consortium comprising the Cattle and Beef Quality Cooperative Research Centre, CSIRO Livestock Industries and Meat and Livestock Australia.

The project identified a particular gene form associated with either beef tenderness or toughness.

This means breeders can improve tenderness by removing animals with two copies of the tough gene and also by selecting to increase the frequency of the tender gene.

According to the CSIRO, gene mapping is low-risk research and is conducted in minimum-security laboratories.

Australia's first cloned and genetically modified calves were born in 2002. They contained an extra gene for milk protein production, which could increase it by 10 per cent.

Unfortunately, due to difficulties in the early stages of development, only one of the four calves survived.

Genetic modification is different from selective breeding. So is it tampering with nature?

What is genetically modified food?

It is food produced from any crop or animal that has been genetically altered during its production, with modifications usually involving changing one of the 30,000 to 50,000 genes making up an organism.

The debate on GM food and its implications for human health continues to rage.

Those in favour would say:

All GM food reaching us has been assessed to meet safety regulations.

Because of gene technology we can have tastier, healthier, nutritionally improved food at a cheaper price because genetic modification helps farmers reduce wastage.

Many GM crops are not substantially changed so there is no need to separate them from unmodified crops. Those against would say:

We don't have conclusive proof GM food is safe.

The technique is imprecise and the science too new to guarantee we won't have problems in the future.

There are already traditional plant and animal breeding techniques that can improve our food.

We can't always choose whether we eat GM food as the current labelling doesn't tell us.

The impact on the environment

Supporters say all GM crops must be carefully assessed for their impact on the environment before they are planted, and that better use can be made of agricultural land as GM crops can grow in conditions unfavourable to traditional crops.

However, opposers say genetic pollution could happen, with unwanted consequences. If this happens, they say, agriculture and the environment will be irreversibly altered.

At the conference, Greenpeace GE campaigner Louise Sales, said despite approval by regulators in many countries, serious concerns remained, including biodiversity impacts, genetic pollution, increased pesticide use and the emergence of pesticide-resistant weeds and insect pests.

"There has been no assessment in Australia of the impacts on native wildlife, beneficial insects, native plants or the ecology of Australia's agricultural areas," she said.

In Australia, cotton and carnations are the only two genetically modified commodities available commercially. The Federal Government has approved canola for commercial release but because of State Government moratoriums it is only being sown in small field trials.

It is estimated at least 70 per cent of processed foods on shelves in the US contain ingredients and oils from biotech crops. The first biotech crop, a tomato, was sold in 1994; the first commodity crop, an insect resistant corn, was sold in 1996. The majority of large commercial farms plant genetically modified crops and there is no effort to distinguish those from non-biotech crops and foods.

In the EU, the issue of whether it is possible to keep GM and conventional crops completely separate is causing much discontent, with 11 GM seeds approved or small commercial plots, while a number of other EU countries have banned GM organisms.

GM firm plans potato trials in Britain

Here's an interesting article on plans for genetically modified potato trials in Great Britian.

Alisa

GM firm plans potato trials in Britain
By Ian Sample
Guardian Unlimited
August 23, 2006

Fields of genetically modified potatoes could be planted in Britain as early as next spring under controversial plans being considered by officials.

The plant science company BASF has applied to the Department for the Environment, Food and Rural Affairs to conduct two field trials of GM potatoes, modified with genes to resist late blight, the fungus that devastated Ireland's potato crop in the famine of the 1840s.

If permission is granted by the environment secretary, David Miliband, the trials will become the first in Britain since the government's field scale trials, which were conducted to assess the environmental implications of GM crop farming and completed in 2003. The prospect of GM crop trials alarmed anti-GM campaigners who fear they could lead to contamination of non-GM food supplies.

The application represents a testing of the water by multinational biotechnology companies since GM crop research was shifted out of Britain en masse in response to the negative public opinion and the widespread trashing of GM crop trials by anti-GM activists.

If the plans are approved, BASF will plant two hectares of GM potatoes in April next year, one in Derbyshire and another at the National Institute for Agricultural Botany in Cambridge. After three to four years of trials the company will seek permission to market, grow and sell the potatoes in Britain.

All of the potatoes grown in the trials must be dug up and transported to laboratories in secure vehicles for testing before being destroyed. Researchers must then observe the field the following season and uproot any remaining potatoes that appear.

The trials would follow ongoing tests of the GM potatoes in Sweden, Germany and the Netherlands. "This would be our first GM trial in the UK and we need to conduct these to see how the crop grows in different conditions," said Barry Stickings of BASF. "I hope that society, including the NGOs, realise that all we are doing is increasing choice."

Late blight (Phytophthora infestans) causes devastating losses to the farming industry, amounting to about £50m each year, despite regular spraying of fungicides. To genetically modify potatoes to resist the blight, researchers at BASF extracted genes from wild relatives of the potato found in Mexico and inserted them into crop potatoes. The genes respond to the fungus by killing off cells around the site of infection, a sacrificial defence that saves the plant from destruction.

If the trials are approved, scientists will infect some GM potatoes with the fungus and wait for natural infection to strike others. They will then assess the effectiveness of the protection.

Andy Beadle, an expert in fungal resistance at BASF, said the risks of contamination from GM crops are minimal because potatoes reproduce through the production of tubers, unlike other crops such as oil seed rape which produces pollen that can be carried for miles on the wind.

Julian Little, spokesman for the GM industry group, the Agricultural Biotechnology Commission, said: "This is a big deal. There have been no trials in this country since the government's field scale trials and the industry is going to be very interested to see how these go."

A Defra spokesman said: "This application will be assessed thoroughly for safety to human health and the environment and considered by the independent experts on the advisory commitee for releases to the environment (Acre)."

Liz Wright, a GM campaigner at Friends of the Earth said: "We have a problem with field trials and with potatoes. The main problem is ensuring you get every scrap of the crop out of the ground afterwards. If you don't manage that, you can get them growing again the next year."

Gains and risks

How are GM crops produced?

Beneficial genes are snipped out of organisms, often other plants, and inserted into the genome of the crop. One way to do this is to use a harmless virus that has been modified to carry the beneficial genes.

Are GM crops grown in Britain?

Not yet, but last year six European countries farmed GM crops.

What are the risks?

Some GM crops, such as oilseed rape, produce pollen that can potentially fertilise non-GM varieties. To minimise the risks, farmers would have to plant these away from other crops. GM potatoes produce a minimal amount of pollen.

How big is the potato market?

Potatoes are the fourth-largest staple food crop in the world. Farmers spend about £20m on fungicides to protect against late blight.

What is the benefit of GM potatoes?

Potatoes are sprayed about 15 times a season to protect them against late blight. GM potatoes would need spraying only a couple of times.

August 22, 2006

California should promote, not ban Genetically Modified Foods

Dr. Henry I. Miller, former head of the FDA Biotechnology Office, a fellow at the Hoover Institution, and author of the book The Frankenfood Myth, wrote a very interesting commentary in the Los Angeles Times recently entitled “The Bounty of Biotech”. In it, he discussed the actions in recent years to forbid the planting genetically modified plants and foods in various counties in California as well as a potential bill that could end these unwarranted and senseless bans.

In his commentary, Dr. Miller talks about politicians and voters in California who, over the past few years, have introduced and passed local ordinances in four California counties to ban the cultivation of plants and crops that have been improved through genetic modification and other state-of-the-art genetic techniques. He called these actions in the California counties of Trinity, Mendocino, Marin, and Santa Cruz democracy at its worst because the measures are unscientific and logically inconsistent, in that their restrictions are inversely related to risk.

Dr. Miller explains that the measures permit the use of microorganisms and plants that are crafted with less precise and predictable techniques but ban those made with more precise and predictable ones. Further, vast numbers of gene-spliced and other bacteria are released routinely from ordinary, low-containment microbiology laboratories without any harmful effects. He points out a study by the Environmental Protection Agency that found that for each technician in such labs, 50 million to 1 billion bacteria on average escape daily-on lab coats, in hair, or just by blowing out the door.

But, there is a far more fundamental issue at stake, Dr. Miller explains. The issue at stake is the freedom of individuals and companies to pursue lawful activities unencumbered. He said that all citizens should be concerned about the implications of subjecting safe and legitimate commercial products-in this case, plants modified though biotechnology, which has been proven to be a safe and superior technology-to surveillance, confiscation, and destruction by local officials who believe they are acting in the “best interest” of their constituents by banning such products.

California legislators are currently debating Senate Bill 1056, a bill introduced a year ago that would prevent local governments from banning genetically modified seeds. Dr. Miller points out that the bill would ensure consistency of regulation throughout the state and prevent farmers from having to navigate a county-by-county patchwork of restrictions and requirements. The bill has the support of virtually all major agricultural organizations, including the California Farm Bureau, Western United Dairymen, Western Growers Association, The Wine Institute, and more.

Dr. Miller explains that banning the cultivation of genetically modified ensures the increased use of chemical pesticides, the persistence of these chemicals in ground and surface water, and resulting in increased occupational exposures. Most important, Dr. Miller points out, is that the county bans are blocking sophisticated genetic approaches to the eradication of blights that threaten a variety of crops and ornamental plants in California. He writes that the potential that biotechnology has is not just theoretical. Through genetic modification, scientists have developed crops that are virus resistant, thus saving many thriving food industries from total devastation. The technology also makes it possible to remove dangerous allergens from wheat, peanuts, and commonly allergenic foods. In addition, genetic modification allows crop varieties to thrive in drought or near-drought conditions.

Further, Dr. Miller says California farmers plant almost a million acres of genetically modified crops annually and Americans have consumed more than a trillion servings of foods that contain biotech ingredients, so the fears and lies that environmental groups and anti-biotech advocates have promoted for years are unwarranted.

It surprises me, even to this day, that people, especially politicians, believe the fear tactics promoted by those against biotechnology and are imposing bans on the technology because they feel genetically modified crops are unproven, unwanted, untested, and unregulated. Common sense proves these fears are not true. There has not been a single documented case of harm to a person or disruption of an ecosystem because of biotechnology. Genetically modified foods are safe and, as Dr. Miller so clearly points out in his commentary, have numerous benefits for both the farmer and the consumer. Letting misguided activism trample science is not good for public policy. Politicians and legislators in California should know and consider all of the facts about biotechnology and genetically modified foods and need to act favorably on Senate Bill 1056. It could impact the future of the individuals they represent, the companies and businesses in their state, and even themselves.

USDA: Genetically engineered rice

Here's another article from the USDA regarding genetically engineered rice.

Alisa

USDA: Genetically engineered rice
August 21, 2006

Genetic engineering (GE) is a precise and predictable method used to introduce new traits into plants and animals by moving genes and other genetic elements from one or more organisms into another organism.

GE crops are being produced that have a wide variety of traits that benefit farmers and consumers. For example, GE crops can tolerate drought conditions and herbicides, resist insects and viruses, and provide enhanced quality and nutrition for consumers. GE crops are being developed by private companies, universities, and other researchers.

GE crops that are currently consumed for food, fiber or feed include corn, soybeans, cotton, canola, alfalfa and squash. Over 70 percent of processed foods on grocery store shelves in the U.S. contain ingredients and oils from biotech crops, according to an industry estimate.

USDA's National Agricultural Statistics Service estimates that in 2006, 61 percent of the corn, 83 percent of the cotton and 89 percent of the soybeans planted in the United States were biotech varieties.

Biotechnology regulatory authority

Under a coordinated regulatory framework, USDA's Animal and Plant Health Inspection Service (APHIS), the Food and Drug Administration (FDA), and the U.S. Environmental Protection Agency (EPA) share responsibility for regulating biotechnology products to ensure that approved biotechnology products developed in the U.S. pose no risk to human health or the environment.

APHIS through its Biotechnology Regulatory Services (BRS) arm is responsible for overseeing the introduction of GE agricultural products in the United States. Since 1987, APHIS has safely deregulated or approved more than 70 GE products.

Deregulation of GE crops is necessary before they can be produced commercially. The process includes several steps including an initial risk assessment and thorough environmental review.

Investigation of regulated rice in commercial rice samples

USDA and FDA have been notified by Bayer CropScience that the company has detected trace amounts of regulated genetically engineered (GE) rice in samples taken from commercial long grain rice.

Both USDA and FDA have reviewed the available scientific data and concluded that there is no human health, food safety, or environmental concerns associated with this GE rice.

Bayer has developed many GE herbicide-tolerant products with the protein called Liberty Link, three of which are rice. The regulated line is LLRICE 601 and Bayer reports finding only trace amounts of it during testing. Bayer conducted field tests of LLRICE 601 between 1998 and 2001. Bayer has indicated it had no plans to market LLRICE 601 and therefore had not petitioned for deregulation.

Two deregulated rice lines, LLRICE 62 and LLRICE 06, have been through thorough safety evaluations and have been deemed safe for use in food and safe in the environment, although these line